Manchester derbies are always special occasions and tonight's match should be no different, with both teams needing three points for different reasons.
United need a victory in our quest to secure a top-four finish, while City will go above Liverpool at the top of the Premier League table with a win.
We've gathered some of the key facts and figures for you ahead of the Old Trafford clash...
Wednesday's game will represent the 178th competitive Manchester derby. We've won 73, drawn 52 and lost 52 to date.
It will also be the 44th league meeting between the clubs in the Premier League era. The Reds have won 21, drawn eight and lost 14.
The Reds are unbeaten in our last 14 Premier League games at Old Trafford, winning nine and drawing five.
This will be only the seventh Premier League meeting between the sides outside of a Saturday or Sunday. The Reds won the first in November 1994 but are winless in the subsequent five.
Wednesday’s match will be our 50th game of the season in all competitions.
The Reds will be looking for a first home win against City since our 4-2 victory on 12 April 2015.
Six members of the current United squad have previously scored against City – Mata, Martial, Pogba, Rashford, Smalling and Young.
Chris Smalling is our top scorer against City in the current squad with three goals, including the winner in last season’s 3-2 victory at the Etihad Stadium.