It's one of the most hotly anticipated games of any season.
When Manchester United face Liverpool, whether at the Merseysiders' Anfield home or, as it will be this weekend, inside a vociferous Old Trafford, the nation comes to a standstill.
Particularly when a certain Cristiano Ronaldo is involved.
The 36-year-old is set to face our Merseyside rivals for the first time since 2009, after his move from Juventus in the summer.
And, while football is a team game and the efforts of all 11 starters and the substitutes will be required for Ole Gunnar Solskjaer's side to emerge victorious on Sunday, Ronaldo's knack for popping up with a winning goal means he's the standout choice in our popular United Predictions game.
Our no.7 is currently 'first scorer' pick for almost half of the users in our Official App, while fans are also backing him to win a second consecutive Man-of-the-Match award, after his late header against Atalanta helped secure that accolade on Wednesday night.
David De Gea, who also excelled in midweek, is second, while Bruno Fernandes is third, despite Solskjaer naming him as an injury doubt for the clash.
In terms of scoreline, you're expecting a tight game, with United 2 Liverpool 1 in front. That was how our last league victory over the Merseysiders finished up, in March 2018, with Marcus Rashford at the double.
For a better idea of how everyone is voting, see our breakdown below. Do you agree? Make your Predictions now...
FIRST SCORER
1. Cristiano Ronaldo (48 per cent)
2. Marcus Rashford (23 per cent)
=3. Bruno Fernandes (11 per cent)
=3. Mason Greenwood (11 per cent)
MAN OF THE MATCH
1. Cristiano Ronaldo (36 per cent)
2. David De Gea (22 per cent)
3. Bruno Fernandes (21 per cent)
CORRECT SCORE
1. United 2 Liverpool 1 (31 per cent)
2. United 2 Liverpool 2 (11 per cent)
3. United 3 Liverpool 2 (10 per cent)