Who has Amorim picked for derby day?
Ruben Amorim has selected the Manchester United side for his first home derby with local rivals City.
Our head coach knows victory in the 16:30 BST kick-off would secure a Premier League double over the Blues, following the 2-1 comeback win at the Etihad Stadium at the end of last year.
United have a crucial Europa League date with Lyon on Thursday, with the quarter-final tie gaining so much importance to the season, but the local affair at Old Trafford this afternoon is sure to be another huge occasion.
Shaw arrives at Old Trafford
ARRIVALS CLIP | Luke Shaw has arrived at Old Trafford! Is he in the squad, or even the XI? Find out at 15:15 BST...
Luke Shaw is back in a matchday squad for the first time since the 4-0 win over Everton on 1 December.
The England defender is among the substitutes, and is joined on the bench by Joshua Zirkzee, with Rasmus Hojlund recalled to the starting XI.
Matthijs de Ligt, flagged as a doubt after picking up an "issue" in the defeat at Nottingham Forest, is absent, as Harry Maguire takes his spot at centre-half, after coming on at The City Ground.
There is a youthful element to a section of the bench with Harry Amass, Godwill Kukonki and Chido Obi all included, but Ayden Heaven is not rushed back.
THE TEAMS
United: Onana; Mazraoui, Maguire, Yoro; Dalot, Casemiro, Ugarte, Dorgu; Garnacho, Fernandes (c); Hojlund.
Substitutes: Bayindir, Amass, Kukonki, Lindelof, Shaw, Eriksen, Mount, Obi, Zirkzee.
City: Ederson; Nunes, Dias, Gvardiol, O'Reilly; Gundogan, Kovacic, De Bruyne (c); Bernardo Silva, Marmoush, Foden.
Substitutes: Ortega, Khusanov, Lewis, Reis, Gonzalez, Grealish, Doku, McAtee, Savinho.