Manchester United are looking to complete the job against Roma by reaching the Europa League final.
Ole Gunnar Solskjaer's Reds came from behind to win the first leg 6-2 at Old Trafford last Thursday, with a devastating display of attacking football.
Despite the four-goal lead, nobody will be taking anything for granted as the two sides meet to decide who will face Villarreal or Arsenal in the final later this month.
Although the Liverpool match on Sunday did not take place, Ole's selection included Mason Greenwood, with Edinson Cavani among the substitutes.
Both strikers are in red-hot form and it will be interesting to see who starts at the Stadio Olimpico, while Eric Bailly is available again and an option to come into defence if the manager decides to freshen things up.
David De Gea started the first leg, and both matches against Granada in the previous round, while Dean Henderson has been keeping goal in the Premier League.
Anthony Martial and Phil Jones have been out through injury while Amad could travel after being left out of the Under-23s' 6-2 win at Derby County on Monday.
Young forwards Anthony Elanga and Shola Shoretire did their senior claims no harm by both scoring doubles in the convincing victory at Loughborough University, in front of the live MUTV cameras.